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If symptoms occur, discontinue zofran and initiate supportive treatment see warnings and precautions .

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Serotonin is produced largely in the gastrointestinal tractWhen a patient undergoes cancer treatmentradiation or chemotherapy drugs can cause specialized cells in the intestine to release serotoninZofran and the other 5-HT3 receptor antagonists work by preventing this serotonin from binding to 5-HT3 receptors.

ZOFRAN is indicated for the prevention of nausea and vomiting associated with:

The FDA had previously noted that ondansetron could increase the risk of developing QT interval prolongationThe agency also pointed to articles published in the medical literature that describe QT interval prolongation with ondansetron.

Do not attempt to push ZOFRAN ODT tablets through the foil backingWith dry handsPEEL BACK the foil backing of 1 blister and GENTLY remove the tabletIMMEDIATELY place the ZOFRAN ODT tablet on top of the tongue where it will dissolve in secondsthen swallow with salivaAdministration with liquid is not necessary.

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